Drug Information

Drug General Information
Drug ID
D09YTY
Former ID
DIB000394
Drug Name
Osutidine
Synonyms
T-593
Drug Type
Small molecular drug
Indication Duodenal ulcers [ICD10:K25-K27] Discontinued in Phase 3 [545064]
Company
Toyama Chemical Co Ltd
Formula
C19H28N4O5S2
Canonical SMILES
S(=O)(=O)(/N=C(\NCC(c1ccc(cc1)O)O)/NCCSCc1oc(cc1)CNC)C
CAS Number
CAS 140695-21-2
PubChem Compound ID
132303
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [525983]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 545064Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002012)
Ref 525983Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50.

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