Drug Information

Drug General Information
Drug ID
D09YTH
Former ID
DIB012977
Drug Name
CPU-228
Synonyms
Dofetilide analog (cardiac failure), China Pharmaceutical University
Drug Type
Small molecular drug
Indication Cardiac failure [ICD10:I50] Investigative [543871]
Company
China Pharmaceutical University
Formula
C23H26N2O4S
Canonical SMILES
c12c(cccc1cccc2)OCCN(CCc1ccc(cc1)NS(=O)(=O)C)C(=O)C
PubChem Compound ID
10025495
Target and Pathway
Target(s) Voltage-dependent L-type calcium channel subunit alpha-1C Target Info Modulator [543866]
Voltage-dependent P/Q-type calcium channel alpha-1A subunit Target Info Modulator [543869]
Voltage-dependent L-type calcium channel alpha-1D subunit Target Info Modulator [543867]
Voltage-dependent R-type calcium channel alpha-1E subunit Target Info Modulator [543871]
Voltage-dependent N-type calcium channel Target Info Modulator [543870]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Insulin secretion
GnRH signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Alzheimer's disease
Amphetamine addiction
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04010:MAPK signaling pathway
Synaptic vesicle cycle
Long-term depression
Taste transduction
Morphine addiction
Nicotine addictionhsa04010:MAPK signaling pathway
Carbohydrate digestion and absorption
Type II diabetes mellitushsa04010:MAPK signaling pathway
Nicotine addiction
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
5HT2 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Oxytocin receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signalingP00003:Alzheimer disease-amyloid secretase pathway
Oxytocin receptor mediated signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
GABA-B receptor II signaling
PathWhiz Pathway Muscle/Heart ContractionPW000619:Pancreas Function
Reactome Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretionR-HSA-112308:Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
WikiPathways Calcium Regulation in the Cardiac Cell
Arrhythmogenic Right Ventricular Cardiomyopathy
Alzheimers Disease
NCAM signaling for neurite out-growth
Integration of energy metabolism
Nicotine Activity on Chromaffin CellsWP536:Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
References
Ref 543871(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534).
Ref 543866(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529).
Ref 543867(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 530).
Ref 543869(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 532).
Ref 543870(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 533).
Ref 543871(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534).

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