Drug Information

Drug General Information
Drug ID
D09WVV
Former ID
DNC011081
Drug Name
N1-(2-aminoethyl)ethane-1,2-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530998]
Formula
C4H13N3
Canonical SMILES
C(CNCCN)N
InChI
1S/C4H13N3/c5-1-3-7-4-2-6/h7H,1-6H2
InChIKey
RPNUMPOLZDHAAY-UHFFFAOYSA-N
PubChem Compound ID
8111
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [530998]
Carbonic anhydrase XII Target Info Inhibitor [530998]
Carbonic anhydrase IX Target Info Inhibitor [530998]
Carbonic anhydrase VI Target Info Inhibitor [530998]
Carbonic anhydrase XIV Target Info Inhibitor [530998]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
References
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

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