Drug Information

Drug General Information
Drug ID
D09WBJ
Former ID
DIB019851
Drug Name
FAUC213
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543338]
Formula
C18H19ClN4
InChI
InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
InChIKey
DTRXURJDKOYCCD-UHFFFAOYSA-N
PubChem Compound ID
10336538
PubChem Substance ID
15347559, 22702396, 24894864, 29217553, 33969600, 57410612, 80496225, 90340760, 103277104, 103999148, 121361873, 134222870, 135650253, 162249129, 163123193, 163565098, 172649982, 175612700, 198984440, 204372599, 241071556, 246246270
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Agonist [527225]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 543338(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 974).
Ref 527225Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Mol Pharmacol. 2004 Dec;66(6):1491-9.Epub 2004 Sep 24.

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