Drug Information

Drug General Information
Drug ID
D09VGC
Former ID
DAP001155
Drug Name
Milnacipran
Synonyms
Ixel; Midalcipran; Milnacipranum; Toledomin; Milnacipran [INN]; Milnacipranum [Latin]; F 2207; F-2207; Ixel (TN); Milnacipran(INN); Savella (TN); (+-)-cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; (-)-Milnacipran; (-)-milnacipran; (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide; 1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane HCl
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536580], [542459]
Therapeutic Class
Antidepressants
Company
Silesia Laboratories
Formula
C15H22N2O
InChI
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3
InChIKey
GJJFMKBJSRMPLA-UHFFFAOYSA-N
CAS Number
CAS 92623-85-3
PubChem Compound ID
11622909
PubChem Substance ID
16725872, 23730579, 50872354, 103564594, 127962305, 137009412, 137821697, 178104008, 179225922, 224351348, 226486589, 249970294
SuperDrug ATC ID
N06AX17
SuperDrug CAS ID
cas=092623853
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [537622]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 542459(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7436).
Ref 537622Milnacipran: Beyond a Role of Antidepressant. Clin Neuropharmacol. 2009 Jun 10.

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