Drug Information

Drug General Information
Drug ID
D09UGP
Former ID
DIB016832
Drug Name
RPR-106541
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [546303]
Company
Aventis Pharma AG
Canonical SMILES
[C@@]12([C@@]3([C@H]([C@H]4[C@@]([C@@]5(C(=CC(=O)CC5)[C<br />@H](C4)F)C)([C@H](C3)O)F)C[C@H]1O[C@H](O2)CCC)C)SC
CAS Number
CAS 159001-35-1
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Agonist [525541]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 546303Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007341)
Ref 525541Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. J Pharmacol Exp Ther. 1999 Aug;290(2):594-602.

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