Drug Information

Drug General Information
Drug ID
D09TEI
Former ID
DIB008761
Drug Name
ReN-1869
Synonyms
Neurin project, ReNeuron; ReN-0189; NNC-05-1869; NNC-47-0189
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [547211]
Company
Novo Nordisk Pharmaceuticals Ltd
Canonical SMILES
C1(=CCCN2C[C@H](C(=O)O)CCC2)c2c(CCc3c1cccc3)cccc2
CAS Number
CAS 170149-99-2
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [526246]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 547211Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014046)
Ref 526246ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57.

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