Drug Information

Drug General Information
Drug ID
D09RON
Former ID
DIB001285
Drug Name
LY-2300559
Synonyms
MGlu2 Pot/Cys (migraine prevention), Eli Lilly; Metabotropic glutamate 2 receptor potentiator/cysteinyl leukotriene receptor 1 antagonist (migraine), Eli Lilly; Mglu2 potentiator/CysLT1 antagonist (migraine prevention), Eli Lilly
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 2 [523139]
Company
Eli Lilly & Co
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator
Cysteinyl leukotriene receptor 1 Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04020:Calcium signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Pathway Interaction Database Endothelins
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 523139ClinicalTrials.gov (NCT01184508) A Study in Migraine Prevention. U.S. National Institutes of Health.

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