Drug Information

Drug General Information
Drug ID
D09QLR
Former ID
DIB012446
Drug Name
Dibenzothiazepines
Synonyms
Cannabinoid CB1 inverse agonists (CNS disorder); Cannabinoid CB1 inverse agonists (CNS disorder), ACADIA; CB1 inverse agonists (obesity, substance abuse), ACADIA
Indication Drug abuse [ICD9: 303-304; ICD10:F10-F19] Investigative [552047]
Company
ACADIA Pharmaceuticals Inc
Canonical SMILES
c1c(cc(c(c1)F)Cl)C1=Nc2cc(ccc2Sc2c1cccc2)C(=O)NCCCC
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Agonist [543877]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 552047Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. J Med Chem. 2009 Apr 9;52(7):1975-82
Ref 543877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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