Drug Information

Drug General Information
Drug ID
D09PWJ
Former ID
DIB020367
Drug Name
ML218
Synonyms
ML-218; ML 218
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542693]
Formula
C19H26Cl2N2O
InChI
InChI=1S/C19H26Cl2N2O/c1-19(2,3)4-5-23-10-16-15(17(16)11-23)9-22-18(24)12-6-13(20)8-14(21)7-12/h6-8,15-17H,4-5,9-11H2,1-3H3,(H,22,24)/t15-,16-,17+
InChIKey
GSJIGYLGKSBYBC-OSYLJGHBSA-N
PubChem Compound ID
45115620
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Blocker (channel blocker) [531818]
Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Blocker (channel blocker) [531818]
Cav3.3 Target Info Blocker (channel blocker) [531818]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainmenthsa04010:MAPK signaling pathway
Circadian entrainment
Type II diabetes mellitus
PANTHER Pathway Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growthWP1866:NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin Cells
References
Ref 542693(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7720).
Ref 531818The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742.

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