Drug Information

Drug General Information
Drug ID
D09PIQ
Former ID
DNC006988
Drug Name
JWH-367
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528355]
Formula
C27H27NO2
Canonical SMILES
CCCCCN1C=C(C=C1C2=CC(=CC=C2)OC)C(=O)C3=CC=CC4=CC=CC=C43
InChI
1S/C27H27NO2/c1-3-4-7-16-28-19-22(18-26(28)21-12-8-13-23(17-21)30-2)27(29)25-15-9-11-20-10-5-6-14-24(20)25/h5-6,8-15,17-19H,3-4,7,16H2,1-2H3
InChIKey
RGYBGMOZXHKLRI-UHFFFAOYSA-N
PubChem Compound ID
44418330
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [528355]
Cannabinoid receptor 2 Target Info Inhibitor [528355]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

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