Drug Information

Drug General Information
Drug ID
D09NEP
Former ID
DIB020414
Drug Name
MRS1088
Synonyms
3,6-dichloroflavone; MRS-1088; NSC-74876
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467628]
Formula
C15H8Cl2O2
InChI
InChI=1S/C15H8Cl2O2/c16-10-6-7-12-11(8-10)14(18)13(17)15(19-12)9-4-2-1-3-5-9/h1-8H
InChIKey
PTNKLWUWHUGKTA-UHFFFAOYSA-N
PubChem Compound ID
252696
PubChem Substance ID
116622, 7703181, 9398640, 15818297, 30050799, 52967525, 103126828, 103274141, 103948332, 104448700, 117468271, 126469437, 135650641, 162785835, 249767477
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Antagonist [534145]
Adenosine A2b receptor Target Info Antagonist [534145]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 467628(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 429).
Ref 534145J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

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