Drug Information

Drug General Information
Drug ID
D09NAJ
Former ID
DNC001121
Drug Name
Phosphoramidon
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538087]
Formula
C23H34N3O10P
Canonical SMILES
CC1C(C(C(C(O1)OP(=O)(NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C<br />32)C(=O)O)O)O)O)O
InChI
1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18+,19+,20+,23-/m0/s1
InChIKey
ZPHBZEQOLSRPAK-XVOJFHBISA-N
CAS Number
CAS 179545-77-8
PubChem Compound ID
134712
PubChem Substance ID
10243716, 29312368, 50059054, 50674845, 57344980, 103072823, 103080015, 104382789, 117541586, 135091555, 136182048, 137157067, 162223978, 232804724, 241147540, 242457137
Target and Pathway
Target(s) Endothelin converting enzyme Target Info Inhibitor [538087]
Neutral endopeptidase Target Info Inhibitor [535034]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 538087In vitro enzymatic processing of radiolabelled big ET-1 in human kidney. Biochem Pharmacol. 1998 Mar 1;55(5):697-701.
Ref 535034Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins. J Invest Dermatol. 2000 Sep;115(3):381-7.
Ref 538087In vitro enzymatic processing of radiolabelled big ET-1 in human kidney. Biochem Pharmacol. 1998 Mar 1;55(5):697-701.

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