Drug Information

Drug General Information
Drug ID
D09MJO
Former ID
DIB001080
Drug Name
HL-004
Synonyms
TS-962
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Preclinical [549199]
Company
Taisho Pharmaceutical Co Ltd
Canonical SMILES
c1(c(C(C)C)cccc1C(C)C)NC(=O)CSCCCCCCCCCCCCCC
CAS Number
CAS 144288-97-1
Target and Pathway
Target(s) Liver carboxylesterase Target Info Modulator [534440]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 549199Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033616)
Ref 534440ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): stimulation of bile acid production by HL-004. Atherosclerosis. 1997 Aug;133(1):97-104.

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