Drug Information

Drug General Information
Drug ID
D09LSY
Former ID
DIB014513
Drug Name
EDP-322
Synonyms
EP-16322; Antibacterial (oral, Gram-positive infections), Enanta; EDP-MRSA-1 (oral), Enanta
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Phase 1 [548796]
Company
Enanta Pharmaceuticals Inc
Canonical SMILES
c1(nc(cs1)N)c1ccc(nc1)CO/N=C/1\CO[C@H]2[C@](C)(O)[C@H](<br />OC(=O)[C@](F)(C)C(=O)[C@@H]([C@H]([C@](OC1)(C[C@H](/C(=<br/>N\C(=O)CC)/[C@@H]2C)C)C)O[C@H]1[C@@H]([C@H](C[C@H](O1)C<br />)N(C)C)O)C)CC
Target and Pathway
Target(s) Multidrug resistance protein 1 Target Info Inhibitor [532939]
KEGG Pathway ABC transporters
Bile secretion
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome ABC-family proteins mediated transport
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Abacavir transport and metabolism
Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Drug Induction of Bile Acid Pathway
Codeine and Morphine Metabolism
References
Ref 548796Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028928)
Ref 532939In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother. 2015 Jan;70(1):173-7.

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