Drug Information

Drug General Information
Drug ID
D09LQP
Former ID
DIB004096
Drug Name
RG-14893
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [544957]
Company
Rhone-Poulenc SA
Formula
C29H27NO4
Canonical SMILES
c1(c2c(cc(C(=O)O)c1)c(OCc1ccccc1)ccc2)CC(=O)N(CCc1ccccc<br />1)C
CAS Number
CAS 141835-49-6
PubChem Compound ID
132379
Target and Pathway
Target(s) Leukotriene B4 receptor 1 Target Info Modulator [534207]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signaling
References
Ref 544957Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001715)
Ref 534207Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain. J Med Chem. 1996 Sep 13;39(19):3756-68.

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