Drug Information

Drug General Information
Drug ID
D09LPG
Former ID
DIB019930
Drug Name
GR 128107
Synonyms
L000276; GR-128107; GR128107
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538825]
Formula
C16H20N2O2
InChI
InChI=1S/C16H20N2O2/c1-11(19)18-7-3-4-12(10-18)15-9-17-16-6-5-13(20-2)8-14(15)16/h5-6,8-9,12,17H,3-4,7,10H2,1-2H3
InChIKey
RBINAFTXZHPTNU-UHFFFAOYSA-N
PubChem Compound ID
44208891
PubChem Substance ID
85209089, 89963267, 135650313, 136351154, 242634192
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [525470]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538825(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1348).
Ref 525470The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores. Br J Pharmacol. 1999 Mar;126(5):1237-45.

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