Drug Information

Drug General Information
Drug ID
D09LKU
Former ID
DIB009635
Drug Name
NOX-E36
Synonyms
Monocyte chemoattractant protein-1 ligand inhibitor(spiegelmer, diabetic complications), NOXXON; MCP-1 inhibitor (spiegelmer/injectable, diabetic complications/diabetic nephropathy), NOXXON
Indication Diabetic complication [ICD10:E08-E13] Phase 2 [523824]
Company
NOXXON Pharma AG
Target and Pathway
Target(s) C-C motif chemokine 2 Target Info Inhibitor [533216]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NOD-like receptor signaling pathway
TNF signaling pathway
Chagas disease (American trypanosomiasis)
Malaria
Influenza A
Herpes simplex infection
Rheumatoid arthritis
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
TWEAK Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
TSLP Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
IL23-mediated signaling events
Reactome Chemokine receptors bind chemokines
ATF4 activates genes
WikiPathways IL1 and megakaryotyces in obesity
Activation of Genes by ATF4
Spinal Cord Injury
Oncostatin M Signaling Pathway
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
IL-1 signaling pathway
GPCR ligand binding
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 523824ClinicalTrials.gov (NCT01547897) NOX-E36 in Patients With Type 2 Diabetes Mellitus and Albuminuria. U.S. National Institutes of Health.
Ref 533216Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2. Nat Commun. 2015 Apr 22;6:6923.

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