Drug Information

Drug General Information
Drug ID
D09KUY
Former ID
DNC012792
Drug Name
4-Chloro-7-methyl-2-phenyl-[1,8]naphthyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525857]
Formula
C15H11ClN2
Canonical SMILES
CC1=NC2=C(C=C1)C(=CC(=N2)C3=CC=CC=C3)Cl
InChI
1S/C15H11ClN2/c1-10-7-8-12-13(16)9-14(18-15(12)17-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey
CMSOCFLZPHQUAD-UHFFFAOYSA-N
PubChem Compound ID
12431921
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [525857]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 525857J Med Chem. 2000 Jul 27;43(15):2814-23.A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.
Ref 525857J Med Chem. 2000 Jul 27;43(15):2814-23.A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.

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