Drug Information

Drug General Information
Drug ID
D09IHN
Former ID
DNC000674
Drug Name
Gamma-acetylenic GABA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537793]
Formula
C6H9NO2
Canonical SMILES
C#CC(CCC(=O)O)N
InChI
1S/C6H9NO2/c1-2-5(7)3-4-6(8)9/h1,5H,3-4,7H2,(H,8,9)
InChIKey
BJNIHWSOVCDBHS-UHFFFAOYSA-N
CAS Number
CAS 57659-38-8
PubChem Compound ID
3452
PubChem Substance ID
5006225, 8152196, 14991980, 17404701, 24278145, 29222586, 47736697, 47810967, 48259451, 49976796, 50105869, 50105870, 50929439, 53777244, 57321809, 85083259, 85230888, 90341196, 92303419, 99233250, 103137657, 103302389, 104303557, 117548193, 121361022, 124749480, 124879068, 125641817, 127524869, 131342051, 132554872, 134223311, 135073038, 138763257, 162092894, 162875550, 163564092, 226984165
Target and Pathway
Target(s) 4-aminobutyrate aminotransferase, mitochondrial Target Info Inhibitor [537793]
BioCyc Pathway GABA shunt
Valine degradation
Beta-alanine degradation
4-aminobutyrate degradation
KEGG Pathway Alanine, aspartate and glutamate metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
Metabolic pathways
GABAergic synapse
PANTHER Pathway Aminobutyrate degradation
Pyrimidine Metabolism
Gamma-aminobutyric acid synthesis
PathWhiz Pathway Aspartate Metabolism
Glutamate Metabolism
Beta-Alanine Metabolism
Valine, Leucine and Isoleucine Degradation
Propanoate Metabolism
WikiPathways GABA synthesis, release, reuptake and degradation
Alanine and aspartate metabolism
References
Ref 537793Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. Neurology. 1981 Feb;31(2):207-11.
Ref 537793Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. Neurology. 1981 Feb;31(2):207-11.

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