Drug Information

Drug General Information
Drug ID
D09GGJ
Former ID
DCL000285
Drug Name
CVT-124
Synonyms
Adentri; Naxifylline; ENX cpd; BG 9719; BG9719; CVT 124; BG-9719; 1,3-ENX; 1,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine; 8-((2S,5,6-Exo)-5,6-epoxy-2-norbonyl)-1,3-dipropylxanthine
Drug Type
Small molecular drug
Indication Autoimmune diabetes [ICD10:E08-E13] Discontinued in Phase 3 [547364]
Company
CV Therapeutics
Formula
C18H24N4O3
Canonical SMILES
CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CC4CC3C5C4O5
InChI
1S/C18H24N4O3/c1-3-5-21-16-12(17(23)22(6-4-2)18(21)24)19-15(20-16)11-8-9-7-10(11)14-13(9)25-14/h9-11,13-14H,3-8H2,1-2H3,(H,19,20)/t9-,10+,11+,13+,14-/m1/s1
InChIKey
OQCJPFYWFGUHIN-VSEIDBEKSA-N
CAS Number
CAS 166374-49-8
PubChem Compound ID
158540
PubChem Substance ID
46233952, 50713112, 53790058, 57348518, 134338941, 135282080, 228904984
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [535721], [551534]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 547364Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015498)
Ref 535721Adenosine receptors and cardiovascular disease: the adenosine-1 receptor (A1) and A1 selective ligands. Cardiovasc Toxicol. 2003;3(1):71-88.
Ref 551534CV Therapeutics. Company report from CV Therapeutics, Inc. CV Therapeutics. 2009.

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