Drug Information

Drug General Information
Drug ID
D09FWP
Former ID
DNC005585
Drug Name
6-(2-Hydroxy-phenyl)-naphthalen-2-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527584]
Formula
C16H12O2
Canonical SMILES
C1=CC=C(C(=C1)C2=CC3=C(C=C2)C=C(C=C3)O)O
InChI
1S/C16H12O2/c17-14-8-7-11-9-13(6-5-12(11)10-14)15-3-1-2-4-16(15)18/h1-10,17-18H
InChIKey
SMFVAKMYNVSVKJ-UHFFFAOYSA-N
PubChem Compound ID
11368353
Target and Pathway
Target(s) Estrogen receptor beta Target Info Inhibitor [527584]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 527584J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.
Ref 527584J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.

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