Drug Information

Drug General Information
Drug ID
D09FQB
Former ID
DIB003894
Drug Name
UR-12460
Indication Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Terminated [545849]
Company
Grupo Uriach
Canonical SMILES
N1(C(=O)CNC(c2ccccc2)c2ccccc2)CCN(C(c2c(nccc2)C)C#N)CC1
CAS Number
CAS 149691-90-7
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator [533626]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545849Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005037)
Ref 533626Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. Br J Pharmacol. 1995 Feb;114(4):895-901.

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