Drug Information

Drug General Information
Drug ID
D09DIG
Former ID
DIB016004
Drug Name
Ablukast
Synonyms
Ablukast sodium; RO-23-3544
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 3 [545175]
Company
Roche Holding AG
Formula
C28H34O8
Canonical SMILES
c1(c(ccc(c1CCC)OCCCCCOc1c(cc2c(OC(C(=O)O)CC2)c1)C(=O)C)<br />C(=O)C)O
PubChem Compound ID
57109
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [1572591]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 545175Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002358)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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