Drug Information

Drug General Information
Drug ID
D09CUJ
Former ID
DIB018675
Drug Name
6-fluoro-noradrenaline
Synonyms
6-fluoronorepinephrine; 6-fluoro-NE ; 5-fluoronorepinephrine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468162]
Formula
C8H10FNO3
InChI
InChI=1S/C8H10FNO3/c9-5-2-7(12)6(11)1-4(5)8(13)3-10/h1-2,8,11-13H,3,10H2
InChIKey
SBUQBFTXTZSRMH-UHFFFAOYSA-N
PubChem Compound ID
1862
PubChem Substance ID
6755092, 8151315, 14992915, 29221057, 47291317, 50110973, 57321049, 79349393, 85229923, 90340696, 103132659, 103202470, 103930103, 104298932, 117509404, 124749542, 124879337, 126407223, 129213635, 135077824, 135649849, 137143200, 138163346, 162219865, 162726282, 227876628, 249511896, 250038890
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Agonist [533826]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 468162(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 510).
Ref 533826Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.

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