Drug Information

Drug General Information
Drug ID
D09AUL
Former ID
DNC012010
Drug Name
Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533684]
Formula
C18H15N5
Canonical SMILES
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)N4C=CN=C4
InChI
1S/C18H15N5/c1-2-6-14(7-3-1)12-20-17-15-8-4-5-9-16(15)21-18(22-17)23-11-10-19-13-23/h1-11,13H,12H2,(H,20,21,22)
InChIKey
FNTPEBIGZTYDQK-UHFFFAOYSA-N
PubChem Compound ID
10266864
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [533684]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [533684]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.

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