Drug Information

Drug General Information
Drug ID
D09AQK
Former ID
DNC000016
Drug Name
(R,S)-4-phosphonophenylglycine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538882]
Formula
C8H10NO5P
InChI
InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
InChIKey
JRQRKFDFHAPMGQ-UHFFFAOYSA-N
PubChem Compound ID
4545574
PubChem Substance ID
6690403, 9568234, 15267431, 26752114, 36859813, 78509769, 85208892, 91746405, 103188541, 103918428, 113102704, 128317786, 134339567, 135371161, 135650421, 152051306, 162189187, 163125509, 170481118, 204430821, 234586300, 241182242
Target and Pathway
Target(s) Metabotropic glutamate receptor 8 Target Info Agonist [534919]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538882(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1406).
Ref 534919Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. Eur J Pharmacol. 1999 Oct 21;383(1):23-7.

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