TTD | Drug: D08ZJM

Drug General Information
Drug ID	D08ZJM
Former ID	DIB020079
Drug Name	isoamyl-agomelatine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542733]
Formula	C20H27NO2
InChI	InChI=1S/C20H27NO2/c1-14(2)5-6-16-11-17-7-8-19(23-4)13-20(17)18(12-16)9-10-21-15(3)22/h7-8,11-14H,5-6,9-10H2,1-4H3,(H,21,22)
InChIKey	DGWFQLYAVLGONI-UHFFFAOYSA-N
PubChem Compound ID	57381997
PubChem Substance ID	136887983, 136941226, 223366114
Target and Pathway
Target(s)	Melatonin receptor	Target Info	Agonist	[531787]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Circadian entrainment
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542733	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7781).
Ref 531787	Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I). Eur J Med Chem. 2012 Mar;49:310-23.

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Drug Information