Drug Information

Drug General Information
Drug ID
D08ZBT
Former ID
DIB015536
Drug Name
SDZ-WAG-994
Synonyms
WAG-994
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 1 [545500]
Company
Novartis AG
Formula
C17H25N5O4
Canonical SMILES
n1([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC)c2c(nc1)c(ncn2)<br />NC1CCCCC1
CAS Number
CAS 130714-47-5
PubChem Compound ID
18755269
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Agonist [533841]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545500Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003507)
Ref 533841The cardiac effects of a novel A1-adenosine receptor agonist in guinea pig isolated heart. J Pharmacol Exp Ther. 1994 Dec;271(3):1371-82.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.