Drug Information

Drug General Information
Drug ID
D08YYY
Former ID
DCL001116
Drug Name
Ocinaplon
Synonyms
CL 273547; Ocinaplon [USAN:INN]; Ocinaplon (USAN/INN); Pyridin-2-yl-(7-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl)methanone; Methanone, 2-pyri(dinyl(7-(4-pyridinyl)pyrazolo(1,5-a)pyrimidin-3-yl); 2-Pyridinyl(7-(4-pyridinyl)pyrazolo(1,5-a)pyrimidin-3-yl)methanone; 2-Pyridyl 7-(4-pyridyl)pyrazolo(1,5-a)pyrimidin-3-yl ketone
Drug Type
Small molecular drug
Indication Generalized anxiety disorder [ICD9: 300, 300.02, 311; ICD10:F32, F40-F42, F41.1] Discontinued in Phase 3 [467614], [544880]
Therapeutic Class
Psychiatric
Company
Dov Pharmaceutical
Formula
C17H11N5O
InChI
InChI=1S/C17H11N5O/c23-16(14-3-1-2-7-19-14)13-11-21-22-15(6-10-20-17(13)22)12-4-8-18-9-5-12/h1-11H
InChIKey
OQJFBUOFGHPMSR-UHFFFAOYSA-N
CAS Number
CAS 96604-21-6
PubChem Compound ID
216456
PubChem Substance ID
9372904, 14849581, 17396787, 30420146, 50065417, 51330410, 57399784, 113461692, 135134778, 135710043, 136032755, 136897486, 137009543, 142916894, 160703450, 163772848, 178101094, 179151481, 198982742, 226493904, 241376979, 249618169, 252158037, 252356365
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [531560]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467614(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4277).
Ref 544880Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001407)
Ref 531560Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.

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