Drug Information

Drug General Information
Drug ID
D08WYM
Former ID
DAP001051
Drug Name
Nafarelin
Synonyms
Nafarelina; Nafareline; Nafarelinum; Synarel; NAFARELIN ACETATE; Nafarelina [Spanish]; Nafareline [French]; Nafarelinum [Latin]; HS-2018; Nafarelin (INN); Nafarelin Acetate, Hydrate; Nafarelin [INN:BAN]; Synarel (TN); RS-94991-298; 6-(3-(2-Naphthalenyl)-D-alanine)luteinizing hormone-releasing factor (pig)
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Approved [536361], [540540]
Therapeutic Class
Fertility Agents
Company
Pfizer Pharmaceuticals
Formula
C66H83N17O13
CAS Number
CAS 76932-56-4
PubChem Compound ID
25077405
PubChem Substance ID
7980061, 14768425, 14817298, 14915111, 37101814, 93166918, 93815087, 99031271, 126684441, 136350807, 137260781, 152034457, 162178931, 162224792, 164757916, 164814646, 175267922, 179151125, 179151126, 187072144, 226411546, 241136768, 249719043, 252156596, 252359142
SuperDrug ATC ID
H01CA02
SuperDrug CAS ID
cas=076932564
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Agonist [537095]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 540540(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3902).
Ref 537095Reversible downregulation of endocrine and germinative testicular function (hormonal castration) in the dog with the GnRH-agonist azagly-nafarelin as a removable implant "Gonazon"; a preclinical trial. Theriogenology. 2009 Apr 15;71(7):1037-45. Epub 2009 Feb 23.

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