Drug Information

Drug General Information
Drug ID
D08WOJ
Former ID
DND000045
Drug Name
OBE-101
Indication Obesity [ICD9: 278; ICD10:E66] Phase 2 [521932]
Company
OBEcure
Target and Pathway
Target(s) Histamine H1 receptor Target Info Modulator [544069]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 521932ClinicalTrials.gov (NCT00409305) The Effect of Betahistine on Body Weight in Obese Subjects. U.S. National Institutes of Health.
Ref 544069Betahistine in the treatment of M?ni?re's disease. Neuropsychiatr Dis Treat. 2007 August; 3(4): 429-440.

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