Drug Information

Drug General Information
Drug ID
D08VJI
Former ID
DIB005673
Drug Name
F-14413
Synonyms
Alpha-2 adrenoceptor antagonist (Alzheimer's disease), Pierre Fabre
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [547865]
Company
Pierre Fabre SA
Canonical SMILES
N1CCN=C1[C@@]1(Oc2c(OC1)c(ccc2)F)OC.Cl
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Antagonist [527640]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 547865Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019997)
Ref 527640Activation of noradrenergic transmission by alpha2-adrenoceptor antagonists counteracts deafferentation-induced neuronal death and cell proliferation in the adult mouse olfactory bulb. Exp Neurol. 2005 Aug;194(2):444-56.

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