Drug Information

Drug General Information
Drug ID
D08TLI
Former ID
DIB016191
Drug Name
E-4716
Synonyms
Mapinastine
Indication Respiratory disease [ICD10:J00-J99] Phase 2 [527345]
Company
Laboratorios Dr Esteve SA
Canonical SMILES
c1(nc2c(n1CCOCC)cccc2)CN1CCN(CC1)CCCCn1nccc1.C(=O)(/C=C<br />\C(=O)O)O.C(=O)(/C=C\C(=O)O)O
CAS Number
CAS 179188-69-3
Target and Pathway
Target(s) Histamine H1 receptor Target Info Modulator [527345]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527345Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children. Br J Clin Pharmacol. 2005 Jan;59(1):43-53.
Ref 527345Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children. Br J Clin Pharmacol. 2005 Jan;59(1):43-53.

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