Drug Information

Drug General Information
Drug ID
D08SNX
Former ID
DIB013494
Drug Name
V-11294A
Synonyms
Rolipram derivatives, Napp
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [547058]
Company
Napp Pharmaceutical Group Ltd
Canonical SMILES
c12c(nc(n1)C(C)C)n(cnc2NCC)Cc1cc(OC2CCCC2)c(cc1)OC.Cl
CAS Number
CAS 162278-09-3
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [526464]
Type IV phosphodiesterase Target Info Inhibitor [526464]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [526464]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
References
Ref 547058Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012597)
Ref 526464Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84.

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