Drug Information

Drug General Information
Drug ID
D08OQQ
Former ID
DIB000512
Drug Name
Lavoltidine
Synonyms
Loxtidine; AH-234844; GSK-1023911a; GSK-1040323b; Histamine H2 receptor antagonist (GERD), GlaxoSmithKline; Histamine H2 receptor antagonist (gastroesophageal reflux disorder), GlaxoSmithKline
Drug Type
Small molecular drug
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Discontinued in Phase 2 [544542]
Company
GlaxoSmithKline plc
Formula
C19H29N5O2
Canonical SMILES
c1(cc(ccc1)OCCCNc1nc(nn1C)CO)CN1CCCCC1
CAS Number
CAS 76956-02-0
PubChem Compound ID
55473
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [544366]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 544542Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000092)
Ref 544366New and Future Drug Development for Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2014 January; 20(1): 6-16.

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