Drug Information

Drug General Information
Drug ID
D08NXC
Former ID
DNC014184
Drug Name
1-[(Furan-2(5H)-one)-4-methyl]-desloratadine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530666]
Formula
C24H23ClN2O2
Canonical SMILES
C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)CC4=CC(=O)OC4)C5=C1C=C<br />C=N5
InChI
1S/C24H23ClN2O2/c25-20-5-6-21-19(13-20)4-3-18-2-1-9-26-24(18)23(21)17-7-10-27(11-8-17)14-16-12-22(28)29-15-16/h1-2,5-6,9,12-13H,3-4,7-8,10-11,14-15H2
InChIKey
CHEQBNZJRBHHQT-UHFFFAOYSA-N
PubChem Compound ID
46233181
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [530666]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530666Bioorg Med Chem. 2010 Feb 15;18(4):1626-32. Epub 2010 Jan 4.Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.
Ref 530666Bioorg Med Chem. 2010 Feb 15;18(4):1626-32. Epub 2010 Jan 4.Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.

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