Drug Information

Drug General Information
Drug ID
D08NQW
Former ID
DIB019130
Drug Name
CHPG
Synonyms
2-chloro-5-hydroxyphenylglycine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538894]
Formula
C8H8ClNO3
InChI
InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
InChIKey
UNIDAFCQFPGYJJ-UHFFFAOYSA-N
PubChem Compound ID
3645780
PubChem Substance ID
4971876, 7978934, 9825754, 14748712, 37841240, 49878618, 53472200, 57356454, 85209021, 91746266, 99300569, 103397322, 103983726, 112087391, 126254323, 135650090, 137147522, 162022804, 162248184, 163125501, 179294118, 204377612, 219630404, 237693946, 241182082
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Agonist [525911]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538894(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1417).
Ref 525911Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.

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