Drug Information

Drug General Information
Drug ID
D08NDV
Former ID
DNC013303
Drug Name
4-(1H-indol-3-yl)-1-morpholinobutan-1-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528710]
Formula
C16H20N2O2
Canonical SMILES
C1COCCN1C(=O)CCCC2=CNC3=CC=CC=C32
InChI
1S/C16H20N2O2/c19-16(18-8-10-20-11-9-18)7-3-4-13-12-17-15-6-2-1-5-14(13)15/h1-2,5-6,12,17H,3-4,7-11H2
InChIKey
YFXYLXOHDNYDNC-UHFFFAOYSA-N
PubChem Compound ID
645040
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [528710]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 528710Bioorg Med Chem Lett. 2007 May 1;17(9):2414-20. Epub 2007 Feb 17.Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.
Ref 528710Bioorg Med Chem Lett. 2007 May 1;17(9):2414-20. Epub 2007 Feb 17.Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.

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