Drug Information

Drug General Information
Drug ID
D08NDE
Former ID
DIB007143
Drug Name
BLZ-945
Synonyms
BLZ-945; CSF-1R inhibitor (bone cancer); CSF-1R inhibitor (bone cancer), Novartis
Drug Type
Small molecular drug
Indication Bone cancer [ICD10:C41.0] Investigative [543010]
Company
Novartis Institutes for BioMedical Research Inc
Formula
C20H22N4O3S
InChI
InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1
InChIKey
ADZBMFGQQWPHMJ-RHSMWYFYSA-N
PubChem Compound ID
46184986
PubChem Substance ID
96038332, 99384427, 120455457, 137626297, 144221040, 172650638, 198979862, 224164069, 228765686, 242078852, 249098261, 249565930, 251910648, 252476072, 252543469
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Inhibitor [543466]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 543010(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8250).
Ref 543466(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).

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