Drug Information

Drug General Information
Drug ID
D08HQK
Former ID
DAP001431
Drug Name
Tetracaine
Synonyms
Amethocaine; Anetain; Contralgin; Dicain; Dicaine; Dikain; Fissucain; Intercain; Laudocaine; Medicaine; Meethobalm; Metraspray; Mucaesthin; Niphanoid; Pontocaine; Rexocaine; Tetracaina; Tetracainum; Tetrakain; Uromucaesthin; Tetrakain [Czech]; Amethocaine (TN); Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;Diaethylaminoaethanol ester der p-butylaminobenzoesaeure [German]; Medihaler-Tetracaine; Pontocaine (TN); Tetracaina [INN-Spanish]; Tetracaine [USAN:INN]; Tetracainum [INN-Latin]; Dimethylaminoethyl p-butyl-aminobenzoate; Tetracaine (USP/INN); P-Butylaminobenzoyl-2-dimethylaminoethanol; BENZOIC ACID,4-BUTYLAMINO,2-DIMETHYLAMINOETHYL ESTER PANTOCAIN BASE; P-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester; BENZOIC ACID, p-(BUTYLAMINO)-, 2-(DIMETHYLAMINO)ETHYL ESTER; Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester; 2-(Dimethylamino)ethyl 4-(butylamino)benzoate; 2-(Dimethylamino)ethyl p-(butylamino)benzoate; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove [Czech]; 2-dimethylaminoethyl 4-(butylamino)benzoate; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester; 4-[Butylamino]benzoic acid-2-[dimethylamino]ethyl ester
Drug Type
Small molecular drug
Indication Spinal anesthesia [ICD9: 338; ICD10:R20.0] Approved [535622]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 2 [551871]
Therapeutic Class
Anesthetics
Formula
C15H24N2O2
Canonical SMILES
CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChIKey
GKCBAIGFKIBETG-UHFFFAOYSA-N
CAS Number
CAS 94-24-6
PubChem Compound ID
5411
PubChem Substance ID
9729, 588146, 5641339, 7847617, 7980764, 8153329, 10538471, 11111916, 11111917, 11335782, 11361021, 11363926, 11366488, 11369050, 11371544, 11373920, 11377212, 11461993, 11466599, 11467719, 11485191, 11486337, 11489144, 11490378, 11492166, 11494846, 15221665, 24900174, 24900448, 29224463, 47291115, 47885396, 47885397, 47885398, 47959731, 48035103, 48259217, 48334477, 49698891, 49886256, 50111267, 50602921, 57309767, 57322762, 57654695, 85089751, 85171696, 85787844, 88826460, 90340576
SuperDrug ATC ID
C05AD02; D04AB06; N01BA03; S01HA03
SuperDrug CAS ID
cas=000094246
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Inhibitor [535913]
Reactome Interaction between L1 and Ankyrins
References
Ref 535622Evaluation of a novel topical anesthetic agent for cutaneous laser resurfacing: a randomized comparison study. Dermatol Surg. 2002 Nov;28(11):1004-6; discussion 1006.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535913Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23. Neuropharmacology. 2004 Mar;46(3):425-38.

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