Drug Information

Drug General Information
Drug ID
D08HIH
Former ID
DIB001036
Drug Name
ERB-196
Synonyms
WAY-196; WAY-202196; Estrogen receptor beta agonist (oral, inflammation/sepsis), Wyeth
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Discontinued in Phase 1 [548018]
Company
Wyeth
Canonical SMILES
c1(c2c(cc(c3cc(c(cc3)O)F)c1)ccc(c2)O)C#N
CAS Number
CAS 550997-55-2
Target and Pathway
Target(s) Estrogen receptor beta Target Info Agonist [528229]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 548018Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021229)
Ref 528229WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med. 2006 Aug;34(8):2188-93.

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