Drug Information

Drug General Information
Drug ID
D08EVM
Former ID
DIB001034
Drug Name
FR-128998
Indication Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] Terminated [545711]
Company
Fujisawa Pharmaceutical Co Ltd
Canonical SMILES
S1(=O)(=O)[C@@]2(CC(=O)N(CC1)Cc1cnccc1)[C@H](Cc1ccccc1)<br />CCCC2.Cl
CAS Number
CAS 133321-57-0
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator [533881]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545711Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004313)
Ref 533881Effect of FR128998, a novel PAF receptor antagonist, on endotoxin-induced disseminated intravascular coagulation. Eur J Pharmacol. 1994 Jun 13;258(3):239-46.

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