Drug Information

Drug General Information
Drug ID
D08ECB
Former ID
DIB000844
Drug Name
LAS-101057
Synonyms
LAS-38096; Adenosine A2b receptor antagonists (inflammation), Almirall
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Preclinical [540986], [548701]
Company
Almirall Prodesfarma SA
Formula
C17H12N6O
InChI
InChI=1S/C17H12N6O/c1-3-12(9-18-6-1)22-17-20-10-13(14-5-7-19-11-21-14)16(23-17)15-4-2-8-24-15/h1-11H,(H,20,22,23)
InChIKey
YRPIMMMBNUUYLG-UHFFFAOYSA-N
PubChem Compound ID
11716665
PubChem Substance ID
16821662, 23806216, 74825262, 103517194, 103905599, 104087803, 162661590, 172652244, 178102251, 198942020, 215778425, 223370130, 223573721, 224142848, 231091553, 243734667, 252553891
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [532805]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540986(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5617).
Ref 548701Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027811)
Ref 532805Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Med Chem Lett. 2010 Dec 20;2(3):213-8.

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