Drug Information

Drug General Information
Drug ID
D08CKJ
Former ID
DIB012702
Drug Name
Fonsartan
Synonyms
HR-720; Hoe-720
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [545886]
Company
Hoechst Marion Roussel Inc; Hoechst AG
Canonical SMILES
S(=O)(=O)([N-]C(=O)NCCC)c1c(c2ccc(Cn3c(c(nc3CCCC)SC)C(=<br />O)[O-])cc2)cccc1.[K+].[K+]
CAS Number
CAS 153235-15-5
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Modulator [534815]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin system
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 545886Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005209)
Ref 534815Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.

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