Drug Information

Drug General Information
Drug ID
D08BGY
Former ID
DNC005869
Drug Name
SCH-37370
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544522]
Formula
C21H21ClN2O
Canonical SMILES
CC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
InChI
1S/C21H21ClN2O/c1-14(25)24-11-8-15(9-12-24)20-19-7-6-18(22)13-17(19)5-4-16-3-2-10-23-21(16)20/h2-3,6-7,10,13H,4-5,8-9,11-12H2,1H3
InChIKey
FLTBEMVEAFMWDD-UHFFFAOYSA-N
PubChem Compound ID
60680
PubChem Substance ID
8186999, 14925522, 43118039, 50610779, 85230050, 103171233, 103920748, 104321368, 117571481, 126422345, 127865452, 134339368, 134340508, 134343074, 135017407, 135651026, 142408277, 198952725, 224941798, 229121344
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator [529095]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544522Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000047)
Ref 529095Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents Actions Suppl. 1991;34:313-21.

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