Drug Information

Drug General Information
Drug ID
D08AJS
Former ID
DNC005879
Drug Name
3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529313]
Formula
C11H7ClN4O
Canonical SMILES
C1=CC2=NC(=C3C=C(NN3)Cl)C(=O)N=C2C=C1
InChI
1S/C11H7ClN4O/c12-9-5-8(15-16-9)10-11(17)14-7-4-2-1-3-6(7)13-10/h1-5,15-16H/b10-8-
InChIKey
IBGKQIYBXOKNFP-NTMALXAHSA-N
PubChem Compound ID
11139437
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [529313]
Adenosine A1 receptor Target Info Inhibitor [529313]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 529313J Med Chem. 2008 Mar 27;51(6):1764-70. Epub 2008 Feb 13.Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
Ref 529313J Med Chem. 2008 Mar 27;51(6):1764-70. Epub 2008 Feb 13.Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.

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