Drug Information

Drug General Information
Drug ID
D07YTL
Former ID
DIB018994
Drug Name
BMS753
Synonyms
BMS-753; BMS 753
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539717]
Formula
C21H21NO4
InChI
InChI=1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25)
InChIKey
KFBPBWUZXBYJDG-UHFFFAOYSA-N
PubChem Compound ID
9884820
PubChem Substance ID
14852003, 24171672, 45631761, 75062735, 118043377, 128373148, 135650006, 142320933, 232852689, 241376480, 249617889, 252157311
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Agonist [525545]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539717(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2650).
Ref 525545Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999 Aug;6(8):519-29.

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