Drug Information

Drug General Information
Drug ID
D07XXK
Former ID
DNC003642
Drug Name
6-(Biphenyl-2-sulfonyl)-2H-pyridazin-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527771]
Formula
C16H12N2O3S
Canonical SMILES
C1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)C3=NNC(=O)C=C3
InChI
1S/C16H12N2O3S/c19-15-10-11-16(18-17-15)22(20,21)14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11H,(H,17,19)
InChIKey
PICCQCWBQAQOHS-UHFFFAOYSA-N
PubChem Compound ID
10267673
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [527771]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 527771J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Ref 527771J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

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