Drug Information

Drug General Information
Drug ID
D07WSR
Former ID
DIB007216
Drug Name
TS-032
Synonyms
PF-04802540; PF-4802540; MGluR agonists (schizophrenia), Taisho; Metabotropic glutamate receptor agonists (schizophrenia), Taisho; MGluR agonists (schizophrenia), Taisho/Pfizer; Metabotropic glutamate receptor agonists (schizophrenia), Taisho/Pfizer
Indication Schizophrenia [ICD9: 295; ICD10:F20] Discontinued in Phase 1 [522628]
Company
Taisho Pharmaceutical Co Ltd
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Agonist [551192]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 522628ClinicalTrials.gov (NCT00876304) Multiple Dose Safety Study of PF-04802540 in Subjects With Schizophrenia. U.S. National Institutes of Health.
Ref 551192Metabotropic glutamate receptor subtype 2/3 (mGluR2/3); serotonin receptor (5-HT2A receptor). SciBX 1(6); doi:10.1038/scibx.2008.145. March 6 2008

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